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DNA Sequence Variation in a 3.7-kb Noncoding Sequence 5′ of the CYP1A2 Gene: Implications for Human Population History and Natural Selection

CYP1A2 is a cytochrome P450 gene that is involved in human physiological responses to a variety of drugs and toxins. To investigate the role of population history and natural selection in shaping genetic diversity in CYP1A2, we sequenced a 3.7-kb region 5′ from CYP1A2 in a diverse collection of 113...

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Detalhes bibliográficos
Main Authors: Wooding, S. P., Watkins, W. S., Bamshad, M. J., Dunn, D. M., Weiss, R. B., Jorde, L. B.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society of Human Genetics 2002
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC379190/
https://ncbi.nlm.nih.gov/pubmed/12181774
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