Urocortin 2 autocrine/paracrine and pharmacologic effects to activate AMP-activated protein kinase in the heart

Urocortin 2 (Ucn2), a peptide of the corticotropin-releasing factor (CRF) family, binds with high affinity to type 2 CRF receptors (CRFR2) on cardiomyocytes and confers protection against ischemia/reperfusion. The mechanisms by which the Ucn2-CRFR2 axis mitigates against ischemia/reperfusion injury...

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Hlavní autoři: Li, Ji, Qi, Dake, Cheng, Haiying, Hu, Xiaoyue, Miller, Edward J., Wu, Xiaohong, Russell, Kerry S., Mikush, Nicole, Zhang, Jiasheng, Xiao, Lei, Sherwin, Robert S., Young, Lawrence H.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2013
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3791748/
https://ncbi.nlm.nih.gov/pubmed/24043794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1312775110
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