Somatic GNAS Mutation Causes Widespread and Diffuse Pituitary Disease in Acromegalic Patients with McCune-Albright Syndrome

CONTEXT: McCune-Albright syndrome (MAS) is caused by sporadic mutations of the GNAS. Patients exhibit features of acromegaly. In most patients, GH-secreting pituitary adenomas have been held responsible for this presentation. However, surgical adenomectomy rarely eliminates excess GH production. OBJ...

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Main Authors: Vortmeyer, Alexander O., Gläsker, Sven, Mehta, Gautam U., Abu-Asab, Mones S., Smith, Jonathan H., Zhuang, Zhengping, Collins, Michael T., Oldfield, Edward H.
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2012
Assuntos:
Endocrine Care
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3791436/
https://ncbi.nlm.nih.gov/pubmed/22564667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2012-1274
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