Dynamics of Nuclear Receptor Helix-12 Switch of Transcription Activation by Modeling Time-Resolved Fluorescence Anisotropy Decays

Nuclear hormone receptors (NRs) are major targets for pharmaceutical development. Many experiments demonstrate that their C-terminal Helix (H12) is more flexible in the ligand-binding domains (LBDs) without ligand, this increased mobility being correlated with transcription repression and human dise...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
Main Authors: Batista, Mariana R.B., Martínez, Leandro
Format: Artigo
Jezik:Inglês
Izdano: The Biophysical Society 2013
Teme:
Proteins and Nucleic Acids
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3791304/
https://ncbi.nlm.nih.gov/pubmed/24094408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2013.07.032
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki