Histone H3 Glutathionylation in Proliferating Mammalian Cells Destabilizes Nucleosomal Structure

Aims: Here we report that chromatin, the complex and dynamic eukaryotic DNA packaging structure, is able to sense cellular redox changes. Histone H3, the only nucleosomal protein that possesses cysteine(s), can be modified by glutathione (GSH). Results: Using Biotin labeled glutathione ethyl ester (...

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Detalhes bibliográficos
Main Authors: García-Giménez, José Luis, Olaso, Gloria, Hake, Sandra B., Bönisch, Clemens, Wiedemann, Sonja M., Markovic, Jelena, Dasí, Francisco, Gimeno, Amparo, Pérez-Quilis, Carme, Palacios, Òscar, Capdevila, Mercè, Viña, José, Pallardó, Federico V.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2013
Assuntos:
Original Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3791047/
https://ncbi.nlm.nih.gov/pubmed/23541030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2012.5021
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