Integration Profile and Safety of an Adenovirus Hybrid-Vector Utilizing Hyperactive Sleeping Beauty Transposase for Somatic Integration

We recently developed adenovirus/transposase hybrid-vectors utilizing the previously described hyperactive Sleeping Beauty (SB) transposase HSB5 for somatic integration and we could show stabilized transgene expression in mice and a canine model for hemophilia B. However, the safety profile of these...

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Hauptverfasser: Zhang, Wenli, Muck-Hausl, Martin, Wang, Jichang, Sun, Chuanbo, Gebbing, Maren, Miskey, Csaba, Ivics, Zoltan, Izsvak, Zsuzsanna, Ehrhardt, Anja
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2013
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3790794/
https://ncbi.nlm.nih.gov/pubmed/24124483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0075344
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