Genome-Wide RNAi Screen Reveals Disease-Associated Genes That Are Common to Hedgehog and Wnt Signaling

The Hedgehog (Hh) and Wnt signal transduction pathways are master regulators of embryogenesis and tissue renewal and represent anticancer therapeutic targets. Using genome-wide RNA interference screening in murine cultured cells, we established previously unknown associations between these signaling...

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Autori principali: Jacob, Leni S., Wu, Xiaofeng, Dodge, Michael E., Fan, Chih-Wei, Kulak, Ozlem, Chen, Baozhi, Tang, Wei, Wang, Baolin, Amatruda, James F., Lum, Lawrence
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3790583/
https://ncbi.nlm.nih.gov/pubmed/21266715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2001225
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