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Exposure to Cocaine alters Dynorphin-mediated Regulation of Excitatory Synaptic Transmission in Nucleus Accumbens Neurons

Dysregulation of excitatory synaptic input to nucleus accumbens (NAc) medium spiny neurons (MSNs) underlies a key pathophysiology of drug addiction and addiction-associated emotional and motivational alterations. Dynorphin peptides, which exhibit higher affinity to kappa type opioid receptors, are u...

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Detalhes bibliográficos
Main Authors: Mu, Ping, Panksepp, Jaak, Schlüter, Oliver, Dong, Yan
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3790254/
https://ncbi.nlm.nih.gov/pubmed/21030009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2010.09.014
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