Molecular imaging of drug transit through the blood-brain barrier with MALDI mass spectrometry imaging

Drug transit through the blood-brain barrier (BBB) is essential for therapeutic responses in malignant glioma. Conventional methods for assessment of BBB penetrance require synthesis of isotopically labeled drug derivatives. Here, we report a new methodology using matrix assisted laser desorption io...

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Detalhes bibliográficos
Main Authors: Liu, Xiaohui, Ide, Jennifer L., Norton, Isaiah, Marchionni, Mark A., Ebling, Maritza C., Wang, Lan Y., Davis, Erin, Sauvageot, Claire M., Kesari, Santosh, Kellersberger, Katherine A., Easterling, Michael L., Santagata, Sandro, Stuart, Darrin D., Alberta, John, Agar, Jeffrey N., Stiles, Charles D., Agar, Nathalie Y. R.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3790202/
https://ncbi.nlm.nih.gov/pubmed/24091529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep02859
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