Microbead-based biomimetic synthetic neighbors enhance survival and function of rat pancreatic β-cells

Diabetes is caused by the loss or dysfunction of insulin-secreting β-cells in the pancreas. β-cells reduce their mass and lose insulin-producing ability in vitro, likely due to insufficient cell-cell and cell-extracellular matrix (ECM) interactions as β-cells lose their native microenvironment. Here...

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Main Authors: Li, Wei, Lee, Samuel, Ma, Minglin, Kim, Soo Min, Guye, Patrick, Pancoast, James R., Anderson, Daniel G., Weiss, Ron, Lee, Richard T., Hammond, Paula T.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3790197/
https://ncbi.nlm.nih.gov/pubmed/24091640
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep02863
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