Chronic Therapy with a Partial Adenosine A1 Receptor Agonist, Improves Left Ventricular Function and Remodeling in Dogs with Advanced Heart Failure

BACKGROUND: Adenosine (AD) elicits cardioprotection through A1-receptor (A1R) activation. Therapy with AD A1R agonists, however, is limited by undesirable actions of full agonism such as bradycardia. This study examined the effects of capadenoson (CAP), a partial AD A1R agonist, on left ventricular...

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Main Authors: Sabbah, Hani N., Gupta, Ramesh C., Kohli, Smita, Wang, Mengjun, Rastogi, Sharad, Zhang, Kefei, Zimmermann, Katja, Diedrichs, Nicole, Albrecht-Küpper, Barbara E.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3790141/
https://ncbi.nlm.nih.gov/pubmed/23564604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCHEARTFAILURE.112.000208
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