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A TSC signaling node at the peroxisome regulates mTORC1 and autophagy in response to ROS

Subcellular localization is emerging as an important mechanism for mTORC1 regulation. We report that the tuberous sclerosis complex (TSC) signaling node, TSC1, TSC2 and Rheb, localizes to peroxisomes, where it regulates mTORC1 in response to reactive oxygen species (ROS). TSC1 and TSC2 were bound by...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Zhang, Jiangwei, Kim, Jinhee, Alexander, Angela, Cai, Shengli, Tripathi, Durga Nand, Dere, Ruhee, Tee, Andrew R., Tait-Mulder, Jacqueline, Di Nardo, Alessia, Han, Juliette M., Kwiatkowski, Erica, Dunlop, Elaine A., Dodd, Kayleigh M., Folkerth, Rebecca D., Faust, Phyllis L., Kastan, Michael B., Sahin, Mustafa, Walker, Cheryl Lyn
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: 2013
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3789865/
https://ncbi.nlm.nih.gov/pubmed/23955302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb2822
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