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A TSC signaling node at the peroxisome regulates mTORC1 and autophagy in response to ROS
Subcellular localization is emerging as an important mechanism for mTORC1 regulation. We report that the tuberous sclerosis complex (TSC) signaling node, TSC1, TSC2 and Rheb, localizes to peroxisomes, where it regulates mTORC1 in response to reactive oxygen species (ROS). TSC1 and TSC2 were bound by...
Αποθηκεύτηκε σε:
Κύριοι συγγραφείς: | , , , , , , , , , , , , , , , , , |
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Μορφή: | Artigo |
Γλώσσα: | Inglês |
Έκδοση: |
2013
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Θέματα: | |
Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3789865/ https://ncbi.nlm.nih.gov/pubmed/23955302 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb2822 |
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