A Mutation in the SUV39H2 Gene in Labrador Retrievers with Hereditary Nasal Parakeratosis (HNPK) Provides Insights into the Epigenetics of Keratinocyte Differentiation

Hereditary nasal parakeratosis (HNPK), an inherited monogenic autosomal recessive skin disorder, leads to crusts and fissures on the nasal planum of Labrador Retrievers. We performed a genome-wide association study (GWAS) using 13 HNPK cases and 23 controls. We obtained a single strong association s...

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Autori principali: Jagannathan, Vidhya, Bannoehr, Jeanette, Plattet, Philippe, Hauswirth, Regula, Drögemüller, Cord, Drögemüller, Michaela, Wiener, Dominique J., Doherr, Marcus, Owczarek-Lipska, Marta, Galichet, Arnaud, Welle, Monika M., Tengvall, Katarina, Bergvall, Kerstin, Lohi, Hannes, Rüfenacht, Silvia, Linek, Monika, Paradis, Manon, Müller, Eliane J., Roosje, Petra, Leeb, Tosso
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2013
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3789836/
https://ncbi.nlm.nih.gov/pubmed/24098150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1003848
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