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Lipid Receptor S1P(1) Activation Scheme Concluded from Microsecond All-Atom Molecular Dynamics Simulations

Sphingosine 1-phosphate (S1P) is a lysophospholipid mediator which activates G protein–coupled sphingosine 1-phosphate receptors and thus evokes a variety of cell and tissue responses including lymphocyte trafficking, endothelial development, integrity, and maturation. We performed five all-atom 700...

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Main Authors: Yuan, Shuguang, Wu, Rongliang, Latek, Dorota, Trzaskowski, Bartosz, Filipek, Slawomir
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2013
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3789783/
https://ncbi.nlm.nih.gov/pubmed/24098103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1003261
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