Mu-opioid receptor A118G polymorphism in healthy volunteers affects hypothalamic–pituitary–adrenal axis adrenocorticotropic hormone stress response to metyrapone

The mu-opioid receptor encoded by the gene OPRM1 plays a primary role in opiate, alcohol, cocaine and nicotine addiction. Studies using opioid antagonists demonstrate that the mu-opioid receptor (MOP-r) also mediates the hypothalamic–pituitary–adrenal (HPA) axis stress response. A common polymorphis...

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Hlavní autoři: Ducat, Elizabeth, Ray, Brenda, Bart, Gavin, Umemura, Yoshie, Varon, Jack, Ho, Ann, Kreek, Mary Jeanne
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3789604/
https://ncbi.nlm.nih.gov/pubmed/21507151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1369-1600.2011.00313.x
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