Systemic siRNA Delivery via Peptide-Tagged Polymeric Nanoparticles, Targeting PLK1 Gene in a Mouse Xenograft Model of Colorectal Cancer

Polymeric nanoparticles were developed from a series of chemical reactions using chitosan, polyethylene glycol, and a cell-targeting peptide (CP15). The nanoparticles were complexed with PLK1-siRNA. The optimal siRNA loading was achieved at an N : P ratio of 129.2 yielding a nanoparticle size of >...

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Dettagli Bibliografici
Autori principali: Malhotra, Meenakshi, Tomaro-Duchesneau, Catherine, Saha, Shyamali, Prakash, Satya
Natura: Artigo
Lingua:Inglês
Pubblicazione: Hindawi Publishing Corporation 2013
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3789392/
https://ncbi.nlm.nih.gov/pubmed/24159333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/252531
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