Loss of SHP-2 activity in CD4(+) T cells promotes melanoma progression and metastasis

The Src homology 2 domain-containing tyrosine phosphatase 2 (SHP-2) has been reported to have both tumor-promoting and tumor-suppressing roles in tumorigenesis. However, the role of SHP-2 in tumor immunity remains unclear. Here we observed progressively lower levels of phosphorylated SHP-2 in tumor-...

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Autori principali: Zhang, Tao, Guo, Wenjie, Yang, Yang, Liu, Wen, Guo, Lele, Gu, Yanhong, Shu, Yongqian, Wang, Lu, Wu, Xuefeng, Hua, Zichun, Ke, Yuehai, Sun, Yang, Shen, Yan, Xu, Qiang
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3789150/
https://ncbi.nlm.nih.gov/pubmed/24088816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep02845
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