Dual Role of miR-21 in CD4+ T-Cells: Activation-Induced miR-21 Supports Survival of Memory T-Cells and Regulates CCR7 Expression in Naive T-Cells

Immune cell-type specific miRNA expression patterns have been described but the detailed role of single miRNAs in the function of T-cells remains largely unknown. We investigated the role of miR-21 in the function of primary human CD4+ T-cells. MiR-21 is substantially expressed in T-cells with a mem...

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Autori principali: Smigielska-Czepiel, Katarzyna, van den Berg, Anke, Jellema, Pytrick, Slezak-Prochazka, Izabella, Maat, Henny, van den Bos, Hilda, van der Lei, Roelof Jan, Kluiver, Joost, Brouwer, Elisabeth, Boots, Anne Mieke H., Kroesen, Bart-Jan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2013
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3787993/
https://ncbi.nlm.nih.gov/pubmed/24098447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0076217
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