The dual inhibitory effect of thiostrepton on FoxM1 and EWS/FLI1 provides a novel therapeutic option for Ewing’s sarcoma

The poor prognosis of Ewing’s sarcoma (EWS), together with its high lethal recurrence rate and the side-effects of current treatments, call for novel targeted therapies with greater curative effectiveness and substantially reduced side-effects. The oncogenic chimeric protein EWS/FLI1 is the key mali...

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Bibliografiske detaljer
Main Authors: SENGUPTA, ANIRUDDHA, RAHMAN, MAHBUBUR, MATEO-LOZANO, SILVIA, TIRADO, OSCAR M., NOTARIO, VICENTE
Format: Artigo
Sprog:Inglês
Udgivet: D.A. Spandidos 2013
Fag:
Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3787886/
https://ncbi.nlm.nih.gov/pubmed/23857410
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijo.2013.2016
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