Shank3 Deficiency Induces NMDA Receptor Hypofunction via an Actin-Dependent Mechanism

Shank3, which encodes a scaffolding protein at glutamatergic synapses, is a genetic risk factor for autism. In this study, we examined the impact of Shank3 deficiency on the NMDA-type glutamate receptor, a key player in cognition and mental illnesses. We found that knockdown of Shank3 with a small i...

Full description

Saved in:
Bibliographic Details
Main Authors: Duffney, Lara J., Wei, Jing, Cheng, Jia, Liu, Wenhua, Smith, Katharine R., Kittler, Josef T., Yan, Zhen
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2013
Subjects:
Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3787498/
https://ncbi.nlm.nih.gov/pubmed/24089484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1175-13.2013
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items