Small Molecule-Induced Mitochondrial Disruption Directs Prostate Cancer Inhibition via Unfolded Protein Response Signaling

We previously identified SMIP004 (N-(4-butyl-2-methyl-phenyl) acetamide) as a novel inducer of cancer-cell selective apoptosis of human prostate cancer cells. SMIP004 decreased the levels of positive cell cycle regulators, upregulated cyclin-dependent kinase inhibitors, and resulted in G1 arrest, in...

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Bibliographic Details
Main Authors: Rico-Bautista, Elizabeth, Zhu, Wenhong, Kitada, Shinichi, Ganapathy, Suthakar, Lau, Eric, Krajewski, Stan, Ramirez, Joel, Bush, Jason A., Yuan, Zhimin, Wolf, Dieter A.
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2013
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3787152/
https://ncbi.nlm.nih.gov/pubmed/23902736
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