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Molecular Simulations of Aromatase Reveal New Insights Into the Mechanism of Ligand Binding

CYP19A1, also known as aromatase or estrogen synthetase, is the rate-limiting enzyme in the biosynthesis of estrogens from their corresponding androgens. Several clinically used breast cancer therapies target aromatase. In this work, explicitly solvated all-atom molecular dynamics simulations of aro...

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書誌詳細
主要な著者: Park, Jiho, Czapla, Luke, Amaro, Rommie E.
フォーマット: Artigo
言語:Inglês
出版事項: 2013
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3787069/
https://ncbi.nlm.nih.gov/pubmed/23927370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ci400225w
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