Cholera toxin disrupts barrier function by inhibiting exocyst-mediated trafficking of host proteins to intestinal cell junctions

Cholera toxin (CT), a virulence factor elaborated by Vibrio cholerae, is sufficient to induce the severe diarrhea characteristic of cholera. The enzymatic moiety of CT (CtxA) increases cAMP synthesis in intestinal epithelial cells, leading to chloride ion (Cl−) efflux through the CFTR Cl− channel. T...

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Detalhes bibliográficos
Main Authors: Guichard, Annabel, Moreno, Beatriz Cruz, Aguilar, Berenice, van Sorge, Nina M., Kuang, Jennifer, Kurkciyan, Adrianne A., Wang, Zhipeng, Hang, Saiyu, Pineton de Chambrun, Guillaume P., McCole, Declan F., Watnick, Paula, Nizet, Victor, Bier, Ethan
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3786442/
https://ncbi.nlm.nih.gov/pubmed/24034615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2013.08.001
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