Synthesis and in vitro evaluation of a multifunctional and surface-switchable nanoemulsion platform

We present a multifunctional nanoparticle platform that has targeting moieties shielded by a matrix metalloproteinase-2 (MMP2) cleavable PEG coating. Upon incubation with MMP2 this surface-switchable coating is removed and the targeting ligands become available for binding. The concept was evaluated...

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Hauptverfasser: Gianella, Anita, Mieszawska, Aneta J., Hoeben, Freek J.M., Janssen, Henk M., Jarzyna, Peter A., Cormode, David P., Costa, Kevin D., Rao, Satish, Farokhzad, Omid C., Langer, Robert, Fayad, Zahi A., Mulder, Willem J.M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3786364/
https://ncbi.nlm.nih.gov/pubmed/23877789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c3cc43618g
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