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A double-blind, placebo-controlled trial of topiramate for the treatment of comorbid cocaine and alcohol dependence
BACKGROUND: Topiramate increases GABAergic activity and antagonizes the AMPA/kainate subtype of glutamate receptors. Through these mechanisms of action, topiramate may reduce alcohol and cocaine reward and may reduce alcohol and cocaine craving. Topiramate has been shown to reduce drinking in person...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3786029/ https://ncbi.nlm.nih.gov/pubmed/23810644 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.drugalcdep.2013.05.026 |
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