A double-blind, placebo-controlled trial of topiramate for the treatment of comorbid cocaine and alcohol dependence

BACKGROUND: Topiramate increases GABAergic activity and antagonizes the AMPA/kainate subtype of glutamate receptors. Through these mechanisms of action, topiramate may reduce alcohol and cocaine reward and may reduce alcohol and cocaine craving. Topiramate has been shown to reduce drinking in person...

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Hlavní autoři: Kampman, Kyle M., Pettinati, Helen M., Lynch, Kevin G., Spratt, Kelly, Wierzbicki, Michael R., O’Brien, Charles P.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3786029/
https://ncbi.nlm.nih.gov/pubmed/23810644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.drugalcdep.2013.05.026
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