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Enhancement of Cisplatin [cis-Diammine Dichloroplatinum (II)] Cytotoxicity by O(6)-Benzylguanine Involves Endoplasmic Reticulum Stress()
O(6)-Benzylguanine (BG) enhances cisplatin [cis-diammine dichloroplatinum (II)]-induced cytotoxicity and apoptosis in head and neck cancer cell lines by an unknown mechanism. We investigated the effect of cisplatin with and without BG on two targets of damage: DNA and the endoplasmic reticulum (ER)....
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3785988/ https://ncbi.nlm.nih.gov/pubmed/18664592 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.108.141291 |
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