Aryl Hydrocarbon Receptor-Dependent Retention of Nuclear HuR Suppresses Cigarette Smoke-Induced Cyclooxygenase-2 Expression Independent of DNA-Binding

The aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor that responds to man-made environmental toxicants, has emerged as an endogenous regulator of cyclooxygenase-2 (Cox-2) by a mechanism that is poorly understood. In this study, we first used AhR-deficient (AhR(−/−)) primary p...

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Main Authors: Zago, Michela, Sheridan, Jared A., Nair, Parameswaran, Rico de Souza, Angela, Gallouzi, Imed-Eddine, Rousseau, Simon, Di Marco, Sergio, Hamid, Qutayba, Eidelman, David H., Baglole, Carolyn J.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3785509/
https://ncbi.nlm.nih.gov/pubmed/24086407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0074953
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