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Modifications of Hippocampal Circuits and Early Disruption of Adult Neurogenesis in the Tg2576 Mouse Model of Alzheimer’s Disease

At advanced stages of Alzheimer’s disease, cognitive dysfunction is accompanied by severe alterations of hippocampal circuits that may largely underlie memory impairments. However, it is likely that anatomical remodeling in the hippocampus may start long before any cognitive alteration is detected....

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Krezymon, Alice, Richetin, Kevin, Halley, Hélène, Roybon, Laurent, Lassalle, Jean-Michel, Francès, Bernard, Verret, Laure, Rampon, Claire
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3785457/
https://ncbi.nlm.nih.gov/pubmed/24086745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0076497
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