A Humanized Monoclonal Antibody Specific for Invariant Natural Killer T (iNKT) Cells for In Vivo Depletion

Invariant Natural Killer T (iNKT) cells are a subset of T cells recognizing glycolipid antigens presented by CD1d. Human iNKT cells express a conserved T cell receptor (TCR)-α chain (Vα24-Jα18) paired with a specific beta chain, Vβ11. The cells are both innate-like, with rapid cytokine release, and...

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Autors principals: Scheuplein, Felix, Thariath, Abraham, Macdonald, Susan, Truneh, Alemseged, Mashal, Robert, Schaub, Robert
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3785425/
https://ncbi.nlm.nih.gov/pubmed/24086759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0076692
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