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Redistribution of substrates to adipose tissue promotes obesity in mice with selective insulin resistance in muscle

Obesity and insulin resistance in skeletal muscle are two major factors in the pathogenesis of type 2 diabetes. Mice with muscle-specific inactivation of the insulin receptor gene (MIRKO) are normoglycemic but have increased fat mass. To identify the potential mechanism for this important associatio...

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Auteurs principaux: Kim, Jason K., Michael, M. Dodson, Previs, Stephen F., Peroni, Odile D., Mauvais-Jarvis, Franck, Neschen, Susanne, Kahn, Barbara B., Kahn, C. Ronald, Shulman, Gerald I.
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2000
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC378504/
https://ncbi.nlm.nih.gov/pubmed/10862794
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