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Intramolecular Dynamics within the N-Cap-SH3-SH2 Regulatory Unit of the c-Abl Tyrosine Kinase Reveal Targeting to the Cellular Membrane

c-Abl is a key regulator of cell signaling and is under strict control via intramolecular interactions. In this study, we address changes in the intramolecular dynamics coupling within the c-Abl regulatory unit by presenting its N-terminal segment (N-Cap) with an alternative function in the cell as...

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Detalhes bibliográficos
Main Authors: de Oliveira, Guilherme A. P., Pereira, Elen G., Ferretti, Giulia D. S., Valente, Ana Paula, Cordeiro, Yraima, Silva, Jerson L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3784749/
https://ncbi.nlm.nih.gov/pubmed/23928308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.500926
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