Mutation of the Salt Bridge-forming Residues in the ETV6-SAM Domain Interface Blocks ETV6-NTRK3-induced Cellular Transformation

The ETV6-NTRK3 (EN) chimeric oncogene is expressed in diverse tumor types. EN is generated by a t(12;15) translocation, which fuses the N-terminal SAM (sterile α-motif) domain of the ETV6 (or TEL) transcription factor to the C-terminal PTK (protein-tyrosine kinase) domain of the neurotrophin-3 recep...

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Hlavní autoři: Cetinbas, Naniye, Huang-Hobbs, Helen, Tognon, Cristina, Leprivier, Gabriel, An, Jianghong, McKinney, Steven, Bowden, Mary, Chow, Connie, Gleave, Martin, McIntosh, Lawrence P., Sorensen, Poul H.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2013
Témata:
Cell Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3784708/
https://ncbi.nlm.nih.gov/pubmed/23798677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.475301
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