Dynein Interacts with the Neural Cell Adhesion Molecule (NCAM180) to Tether Dynamic Microtubules and Maintain Synaptic Density in Cortical Neurons

Cytoplasmic dynein is well characterized as an organelle motor, but dynein also acts to tether and stabilize dynamic microtubule plus-ends in vitro. Here we identify a novel and direct interaction between dynein and the 180-kDa isoform of the neural cell adhesion molecule (NCAM). Optical trapping ex...

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Autors principals: Perlson, Eran, Hendricks, Adam G., Lazarus, Jacob E., Ben-Yaakov, Keren, Gradus, Tal, Tokito, Mariko, Holzbaur, Erika L. F.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2013
Matèries:
Cell Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3784697/
https://ncbi.nlm.nih.gov/pubmed/23960070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.465088
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