Common genetic variation at the IL1RL1 locus regulates IL-33/ST2 signaling

The suppression of tumorigenicity 2/IL-33 (ST2/IL-33) pathway has been implicated in several immune and inflammatory diseases. ST2 is produced as 2 isoforms. The membrane-bound isoform (ST2L) induces an immune response when bound to its ligand, IL-33. The other isoform is a soluble protein (sST2) th...

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Main Authors: Ho, Jennifer E., Chen, Wei-Yu, Chen, Ming-Huei, Larson, Martin G., McCabe, Elizabeth L., Cheng, Susan, Ghorbani, Anahita, Coglianese, Erin, Emilsson, Valur, Johnson, Andrew D., Walter, Stefan, Franceschini, Nora, O’Donnell, Christopher J., Dehghan, Abbas, Lu, Chen, Levy, Daniel, Newton-Cheh, Christopher, Lin, Honghuang, Felix, Janine F., Schreiter, Eric R., Vasan, Ramachandran S., Januzzi, James L., Lee, Richard T., Wang, Thomas J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3784527/
https://ncbi.nlm.nih.gov/pubmed/23999434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI67119
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