Renal β-intercalated cells maintain body fluid and electrolyte balance

Inactivation of the B1 proton pump subunit (ATP6V1B1) in intercalated cells (ICs) leads to type I distal renal tubular acidosis (dRTA), a disease associated with salt- and potassium-losing nephropathy. Here we show that mice deficient in ATP6V1B1 (Atp6v1b1(–/–) mice) displayed renal loss of NaCl, K(...

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Main Authors: Gueutin, Victor, Vallet, Marion, Jayat, Maximilien, Peti-Peterdi, Janos, Cornière, Nicolas, Leviel, Françoise, Sohet, Fabien, Wagner, Carsten A., Eladari, Dominique, Chambrey, Régine
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3784520/
https://ncbi.nlm.nih.gov/pubmed/24051376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI63492
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