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Effects on Proliferation and Differentiation of Multipotent Bone Marrow Stromal Cells Engineered to Express Growth Factors for Combined Cell and Gene Therapy

A key mechanism for mesenchymal stem cells/bone marrow stromal cells (MSCs) to promote tissue repair is by secretion of soluble growth factors (GFs). Therefore, clinical application could be optimized by a combination of cell and gene therapies, where MSCs are genetically modified to express higher...

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Detalhes bibliográficos
Main Authors: Fierro, Fernando A., Kalomoiris, Stefanos, Sondergaard, Claus S., Nolta, Jan A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3784258/
https://ncbi.nlm.nih.gov/pubmed/21898687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.720
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