Examination of mesenchymal stem cell-mediated RNAi transfer to Huntington’s disease affected neuronal cells for reduction of huntingtin

Huntington’s disease (HD) is a fatal, autosomal dominant neurodegenerative disorder caused by an expanded trinucleotide (CAG) repeat in exon 1 of the huntingtin gene (Htt). This expansion creates a toxic polyglutamine tract in the huntingtin protein (HTT). Currently, there is no treatment for either...

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Hlavní autoři: Olson, Scott D., Kambal, Amal, Pollock, Kari, Mitchell, Gaela-Marie, Stewart, Heather, Kalomoiris, Stefanos, Cary, Whitney, Nacey, Catherine, Pepper, Karen, Nolta, Jan A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3784251/
https://ncbi.nlm.nih.gov/pubmed/22198539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mcn.2011.12.001
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