Immunotherapy of CD30-expressing lymphoma using a highly stable ssDNA aptamer

CD30 is highly expressed on Hodgkins lymphoma and anaplastic large cell lymphoma, making it an attractive target for therapy. We describe the generation of serum-stabilized ssDNA aptamers that bind CD30 via a hybrid SELEX methodology. The selected aptamer bound CD30 with high affinity and specificit...

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Bibliografiske detaljer
Main Authors: Parekh, Parag, Kamble, Sanchit, Zhao, Nianxi, Zeng, Zihua, Portier, Bryce P., Zu, Youli
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3784013/
https://ncbi.nlm.nih.gov/pubmed/23968853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2013.07.099
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