Arginase inhibition mediates renal tissue protection in diabetic nephropathy by a nitric oxide synthase 3-dependent mechanism

Recently we showed that pharmacological blockade or genetic deficiency of arginase-2 confers kidney protection in diabetic mouse models. Here we tested whether the protective effect of arginase inhibition is nitric oxide synthase-3 (eNOS)-dependent in diabetic nephropathy. Experiments were conducted...

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Bibliographic Details
Main Authors: You, Hanning, Gao, Ting, Cooper, Timothy K., Morris, Sidney M., Awad, Alaa S.
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3783645/
https://ncbi.nlm.nih.gov/pubmed/23760286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ki.2013.215
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