Impact of Nucleotide Mutations at the HNF3- and HNF4-Binding Sites in Enhancer 1 on Viral Replication in Patients with Chronic Hepatitis B Virus Infection

BACKGROUND/AIMS: The hepatitis B virus (HBV) genome contains binding sites for hepatocyte nuclear factors (HNF) 3 and 4 in the core domain of enhancer 1 (Enh1), and mutations in this domain have a strong impact on virus replication. We aimed to identify frequent base-mutation sites in the core domai...

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Main Authors: Cho, Eun-young, Kim, Hyung-jin, Park, Channy, So, Hong-seob, Park, Rae Kil, Kim, Haak Cheoul
Formato: Artigo
Idioma:Inglês
Publicado em: The Korean Society of Gastroenterology; the Korean Society of Gastrointestinal Endoscopy; the Korean Association for the Study of the Liver; the Korean Society of Neurogastroenterology and Motility; Korean Association for the Study of Intestinal Diseases; Korean College of Helicobacter and Upper Gastrointestinal Research; Korean Pancreatobiliary Association; Korean Society of Gastrointestinal Cancer 2013
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3782672/
https://ncbi.nlm.nih.gov/pubmed/24073315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5009/gnl.2013.7.5.569
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