Pipoxolan Ameliorates Cerebral Ischemia via Inhibition of Neuronal Apoptosis and Intimal Hyperplasia through Attenuation of VSMC Migration and Modulation of Matrix Metalloproteinase-2/9 and Ras/MEK/ERK Signaling Pathways

Pipoxolan (PIPO) has anti-spasmodic effects, and it is used clinically to relieve smooth muscle spasms. Cerebrovascular disease is one of the leading causes of disability and death worldwide. The main aim of this study was to investigate the effects of PIPO on cerebral ischemia and vascular smooth m...

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Bibliographische Detailangaben
Hauptverfasser: Chen, Yuh-Fung, Tsai, Huei-Yann, Wu, Kuo-Jen, Siao, Lian-Ru, Wood, W. Gibson
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2013
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3782448/
https://ncbi.nlm.nih.gov/pubmed/24086601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0075654
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