Expression of HIV-1 Vpu Leads to Loss of the Viral Restriction Factor CD317/Tetherin from Lipid Rafts and Its Enhanced Lysosomal Degradation

CD317/tetherin (aka BST2 or HM1.24 antigen) is an interferon inducible membrane protein present in regions of the lipid bilayer enriched in sphingolipids and cholesterol (often termed lipid rafts). It has been implicated in an eclectic mix of cellular processes including, most notably, the retention...

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Hauptverfasser: Rollason, Ruth, Dunstan, Katie, Billcliff, Peter G., Bishop, Paul, Gleeson, Paul, Wise, Helen, Digard, Paul, Banting, George
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2013
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3782430/
https://ncbi.nlm.nih.gov/pubmed/24086611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0075680
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