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Double-stranded RNA binding by the human cytomegalovirus PKR antagonist TRS1

Protein Kinase R (PKR) inhibits translation initiation following double-stranded RNA (dsRNA) binding and thereby represses viral replication. Human cytomegalovirus (HCMV) encodes two noncanonical dsRNA binding proteins, IRS1 and TRS1, and the expression of at least one of these PKR antagonists is es...

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Detalhes bibliográficos
Main Authors: Bierle, Craig J., Semmens, Kathryn M., Geballe, Adam P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3782281/
https://ncbi.nlm.nih.gov/pubmed/23601785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2013.03.024
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