Reducing cell number improves the homing of dendritic cells to lymph nodes upon intradermal vaccination

Dendritic cell (DC)-based vaccines require the cells to relocate to lymph nodes (LNs). Unfortunately, however, DC migration rates are typically very poor. We investigated strategies to increase the migration efficacy of DC-based vaccines. Surprisingly, a reduction in DC number, but not the condition...

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Detalhes bibliográficos
Main Authors: Aarntzen, Erik HJG, Srinivas, Mangala, Schreibelt, Gerty, Heerschap, Arend, Punt, Cornelius JA, Figdor, Carl G, Oyen, Wim J, de Vries, I Jolanda M
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3782158/
https://ncbi.nlm.nih.gov/pubmed/24073362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/onci.24661
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