Neuroprotective intervention by interferon-γ blockade prevents CD8(+) T cell–mediated dendrite and synapse loss

Neurons are postmitotic and thus irreplaceable cells of the central nervous system (CNS). Accordingly, CNS inflammation with resulting neuronal damage can have devastating consequences. We investigated molecular mediators and structural consequences of CD8(+) T lymphocyte (CTL) attack on neurons in...

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Main Authors: Kreutzfeldt, Mario, Bergthaler, Andreas, Fernandez, Marylise, Brück, Wolfgang, Steinbach, Karin, Vorm, Mariann, Coras, Roland, Blümcke, Ingmar, Bonilla, Weldy V., Fleige, Anne, Forman, Ruth, Müller, Werner, Becher, Burkhard, Misgeld, Thomas, Kerschensteiner, Martin, Pinschewer, Daniel D., Merkler, Doron
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3782053/
https://ncbi.nlm.nih.gov/pubmed/23999498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20122143
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