Efficient Use of Exogenous Isoprenols for Protein Isoprenylation by MDA-MB-231 Cells Is Regulated Independently of the Mevalonate Pathway

Mammalian cells can use exogenous isoprenols to generate isoprenoid diphosphate substrates for protein isoprenylation, but the mechanism, efficiency, and biological importance of this process are not known. We developed mass spectrometry-based methods using chemical probes and newly synthesized stab...

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Detalhes bibliográficos
Main Authors: Onono, Fredrick, Subramanian, Thangaiah, Sunkara, Manjula, Subramanian, Karunai Leela, Spielmann, H. Peter, Morris, Andrew J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Lipids
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3779739/
https://ncbi.nlm.nih.gov/pubmed/23908355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.482307
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