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Regulation of Retinoblastoma Protein (Rb) by p21 Is Critical for Adaptation to Massive Small Bowel Resection

BACKGROUND: Adaptation following massive intestinal loss is characterized by increased villus height and crypt depth. Previously, we demonstrated that p21-null mice do not adapt after small bowel resection (SBR). As retinoblastoma protein (Rb) levels are elevated in p21-null crypt cells, we first so...

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Detalhes bibliográficos
Main Authors: Leinicke, Jennifer A., Longshore, Shannon, Wakeman, Derek, Guo, Jun, Warner, Brad W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3779625/
https://ncbi.nlm.nih.gov/pubmed/22042567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11605-011-1747-8
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