Defects of Vps15 in skeletal muscles lead to autophagic vacuolar myopathy and lysosomal disease

The complex of Vacuolar Protein Sorting 34 and 15 (Vps34 and Vps15) has Class III phosphatidylinositol 3-kinase activity and putative roles in nutrient sensing, mammalian Target Of Rapamycin (mTOR) activation by amino acids, cell growth, vesicular trafficking and autophagy. Contrary to expectations,...

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Detalhes bibliográficos
Main Authors: Nemazanyy, Ivan, Blaauw, Bert, Paolini, Cecilia, Caillaud, Catherine, Protasi, Feliciano, Mueller, Amelie, Proikas-Cezanne, Tassula, Russell, Ryan C, Guan, Kun-Liang, Nishino, Ichizo, Sandri, Marco, Pende, Mario, Panasyuk, Ganna
Formato: Artigo
Idioma:Inglês
Publicado em: WILEY-VCH Verlag 2013
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3779449/
https://ncbi.nlm.nih.gov/pubmed/23630012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201202057
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