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Cell-Intrinsic Role for NF-kappa B-Inducing Kinase in Peripheral Maintenance but Not Thymic Development of Foxp3(+) Regulatory T Cells in Mice

NF-κB inducing kinase (NIK, MAP3K14) is a key signaling molecule in non-canonical NF-κB activation, and NIK deficient mice have been instrumental in deciphering the immunologic role of this pathway. Global ablation of NIK prevents lymph node development, impairs thymic stromal development, and drast...

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Bibliografiske detaljer
Hovedforfatter: Murray, Susan E.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3779168/
https://ncbi.nlm.nih.gov/pubmed/24073289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0076216
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