IMGT/HighV QUEST paradigm for T cell receptor IMGT clonotype diversity and next generation repertoire immunoprofiling

T cell repertoire diversity and clonotype follow-up in vaccination, cancer, infectious and immune diseases represent a major challenge owing to the enormous complexity of the data generated. Here we describe a next generation methodology, which combines 5′RACE PCR, 454 sequencing and, for analysis,...

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Main Authors: Li, Shuo, Lefranc, Marie-Paule, Miles, John J., Alamyar, Eltaf, Giudicelli, Véronique, Duroux, Patrice, Freeman, J. Douglas, Corbin, Vincent D. A., Scheerlinck, Jean-Pierre, Frohman, Michael A., Cameron, Paul U., Plebanski, Magdalena, Loveland, Bruce, Burrows, Scott R., Papenfuss, Anthony T., Gowans, Eric J.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Pub. Group 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3778833/
https://ncbi.nlm.nih.gov/pubmed/23995877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms3333
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